Universidad de Costa Rica
Sede del Atlántico
Recinto de Guápiles
Oral communication v
Ectopic pregnancy
Teacher: Robertho Mesén Hidalgo
Work team:
Arce Campos Gabriela
Arias Varela Randall
Barrantes Hernández Verónica
Contreras Obando Tatiana
I semester, 2010
Abstract 3
Background of the problem 3
Justification 4
Problem 5
Terminal objective: 5
Enabling objectives: 6
THEORETICAL FRAMEWORK 6
Ectopic pregnancy: 6
Causes, symptoms, treatment and consequences 6
Terminologies 16
Conclusions 22
Recommendations: 23
Outline 24
References 26
The following work is about ectopic pregnancies, the main factors to take into account in this study, are first of all, generalities about that kind of pregnancies, then we are going to talk about the principal causes for instance: smoking, medications with hormones, birth defects; symptoms for example abdominal pain, bleeding and possible options of treatments such as surgery, injections; another important aspect is the consequences for women that suffer ectopic pregnancies.
Also is important to mention that you can find some conclusions and recommendations about how can you prevent or minimize the risk of suffer an ectopic pregnancy.
Background of the problem
Ectopic pregnancy (EP) also called tubal pregnancies, because the 95% of ectopic pregnancies occur in the uterine tube, are terms used to describe pregnancies occurring outside of the uterus, and this fact is automatically a synonym of fetal loss.
The baby cannot be saved in a tubal ectopic pregnancy. However, with early diagnosis, the pregnancy can be safely ended using medication or surgery. It increases the possibilities of having a normal pregnancy at a later date. Even worst, if left untreated, an ectopic pregnancy can be fatal (it is the main cause of 1st trimester maternal death).
A quotation from Nora Ephron says “if pregnancy were a book they would cut the last two chapters”. We can add “it could be worst if this book ends in an ectopic pregnancy”. For that reason, according to prevent this kind of pregnancy complication, it is important to know more about the generalities, causes, symptoms, diagnosis and treatment.
Justification
This investigation was created in the Universidad de Costa Rica, Sede Del Atlántico, Recinto de Guápiles by a team work during the I semester of 2010, in oral communication V. To continue it is presented and developed the following research.
The team work is pleased to share relevant information to the students about ectopic pregnancy or pregnancy out of place, which it is a risky stage for the sake of many women who are waiting a baby without any knowledge of the abnormal pregnancy, if they are having. It is important to let the people know about the topic because it is a serious problem that women and their families have to confront with strength; the information is not only directed for students, but also for someone else who want to be informed about the case.
It should help to be alert to the signals which appears during this kind of gestation in order to be warned to any complication that could be presented in these period, besides that, to take at time the appropriate treatment in an institution for the sake of the mother’s life; maintaining them in the better conditions as well as possible.
Problem
Nowadays the infant mortality rate is decreasing in our country, but the number of cases of ectopic pregnancies is increasing affecting to the fetus life and causing different problems such as infertility and even death on many women that are in gestation stage within an ectopic. It is important to everybody to know what are the causes, symptoms, the treatment, consequences, and how to prevent it in order to take the appropriated procedure if it is necessary with the goal of save their lives, besides to inform the students of this estrange pregnancy.
Terminal objective:
To recognize the process in which the ectopic pregnancy works in a pregnant woman and some factors related to this phenomenon.
Enabling objectives:
• To distinguish some of the causes of an ectopic pregnancy
• To mention the possible consequences for a woman in a ectopic pregnancy
• To identify different kind of treatments and advices for woman who suffer an ectopic pregnancy
THEORETICAL FRAMEWORK
Ectopic pregnancy:
Causes, symptoms, treatment and consequences
An ectopic pregnancy is that is not in the uterus. The fertilized egg settles and grows in any location other than the inner lining of the uterus. The large majority (95%) of ectopic pregnancies occur in the Fallopian tube. However, they can occur in other locations, such as the ovary, cervix, and abdominal cavity. We have to remember that an ectopic pregnancy occurs in about 1 in 60 pregnancies. Most ectopic pregnancies occur in women 35 to 44 years of age and the major concern with an ectopic pregnancy is internal bleeding.
Before the 19th century, the mortality rate (the death rate) from ectopic pregnancies exceeded 50%. By the end of the 19th century, the mortality rate dropped to five percent because of surgical intervention. With current advances in early detection, the mortality rate has improved to less than five in 10,000. The survival rate from ectopic pregnancies is improving even though the incidence of ectopic pregnancies is also increasing. Ectopic pregnancy remains the leading cause of pregnancy-related death in the first trimester of pregnancy.
It is really important that when a woman knows she is pregnant, make an appointment with her doctor for an examination. Occasionally, the doctor may feel a tender mass during the pelvic examination. If an ectopic pregnancy is suspected, the combination of blood hormone tests and pelvic ultrasound can usually help to establish the diagnosis. Transvaginal ultrasound is the most useful test to visualize an ectopic pregnancy. In this test, an ultrasound probe is inserted into the vagina, and pelvic images are visible on a monitor. Transvaginal ultrasound can reveal the gestational sac in either a normal (intrauterine) pregnancy or an ectopic pregnancy, but often the findings are not conclusive. Rather than a gestational sac containing a visible embryo, the examination may simply reveal a mass in the area of the Fallopian tubes or elsewhere that is suggestive of, but not conclusive for, an ectopic pregnancy. The ultrasound can also demonstrate the absence of pregnancy within the uterus.
The beta subunit of human chorionic gonadotrophin (beta HCG) blood levels are also used in the diagnosis of ectopic pregnancy. Beta HCG levels normally rise during pregnancy. An abnormal pattern in the rise of this hormone can be a clue to the presence of an ectopic pregnancy. In rare cases, laparoscopy may be needed to ultimately confirm a diagnosis of ectopic pregnancy. During laparoscopy, viewing instruments are inserted through three or more small (5-10 mm) incisions that are made in the abdomen to allow access ports to be inserted. The surgeon then uses the laparoscope, which transmits a picture of the abdominal organs on a video monitor, allowing the operation to be performed.
One of the most important test to confirm the diagnosis of ectopic pregnancy is a pelvic exam that is a way for doctors to look for signs of illness in certain organs in a woman's body. The exam is used to look at a woman's: Vulva (external genital organs), Uterus (the womb), Cervix (opening from the vagina to the uterus), Fallopian tubes (tubes that carry eggs to the womb), Ovaries (organs that produce eggs) and the Bladder (the sac that holds urine).
An ectopic pregnancy is usually caused by a condition that blocks or slows the movement of a fertilized egg through the fallopian tube to the uterus. This may be caused by a physical blockage in the tube.
It's important to remember that in most cases of ectopic pregnancy, the cause is unknown. However, several factors can raise your risk for an ectopic pregnancy such as scarring caused by: Past ectopic pregnancy, Past infection or inflammation in the fallopian tubes, Use of an intrauterine contraceptive device (IUD), Surgery of the fallopian tubes or in the pelvic area.
Some ectopic pregnancies can be due also to:
• Birth defects of the fallopian tubes
• Complications of a ruptured appendix
• Endometriosis: Endometriosis (when cells from the lining of the uterus implant and grow elsewhere in the body) or scar tissue from previous abdominal or fallopian surgeries can also cause blockages. More rarely, birth defects or abnormal growths can alter the shape of the tube and disrupt the egg's progress.
• Smoking: is also associated with up to a five times greater risk of ectopic pregnancy. The problem is the nicotine in cigarettes, because it stimulates contractions in the fallopian tubes. This can cause spasm, resulting in temporary blockage of the tube so the embryo cannot pass through.
• Medications: Several hormonal medications like Fertility drugs and Contraceptive hormonal medications that contain progesterone-like hormones have also been associated with ectopic pregnancies, that kind of medications may predispose women to tubal pregnancies by altering the ability of the fallopian tube to contract and squeeze the embryo through to the womb.
Sometimes, a woman will become pregnant after having her tubes tied (tubal sterilization). Ectopic pregnancies are more likely to occur 2 or more years after the procedure, rather than right after it. In the first year after sterilization, only about 6% of pregnancies will be ectopic, but most pregnancies that occur 2 - 3 years after tubal sterilization will be ectopic.
Taking hormones, especially estrogen and progesterone (such as those in birth control pills), can slow the normal movement of the fertilized egg through the tubes and lead to ectopic pregnancy.
Women who have in vitro fertilization or who have an intrauterine device (IUD) using progesterone also have an increased risk of ectopic pregnancy.
The "morning after pill" (emergency contraception) has been linked to some cases of ectopic pregnancy.
What about the future? The chances of having a successful pregnancy after an ectopic pregnancy may be lower than normal, but this will depend on why the pregnancy was ectopic and your medical history. If the fallopian tubes have been left in place, you have approximately a 60% chance of having a successful pregnancy in the future.
Some women have difficulties to be pregnant again. This difficulty is more common in women who also had fertility problems before the ectopic pregnancy. Your prognosis depends on your fertility before the ectopic pregnancy, as well as the extent of the damage that was done.
The likelihood of a repeat ectopic pregnancy increases with each subsequent ectopic pregnancy. Once you have had one ectopic pregnancy, you face an approximate 15% chance of having another.
A important question that the woman make after had an ectopic pregnancy is about the chance to have a normal pregnancy and a successful one and the answer is yes, the earlier you end an ectopic pregnancy, the less damage you'll have in that tube and even if you lost one of your tubes, you can still have a normal pregnancy as long as your other tube is normal.
But if you're unable to conceive because of ectopic pregnancies or damaged tubes, the good news is that you're likely to be an excellent candidate for fertility treatments such as in vitro fertilization (IVF), in which your healthy embryos are implanted directly in your uterus.
An important consequence of the ectopic pregnancy is the feeling of devastated by the experience. Also the recovering from major surgery is one of the main consequences, which can leave the person exhausted and numb, or suffering from hormonal ups and downs that can leave you feeling depressed and vulnerable.
The person need time to recuperate emotionally and physically before trying for another baby. Most caregivers will advise the person to wait at least three months after major abdominal surgery for your body to heal.
In the emotional part, is very important to say that the partner may also be feeling sad or helpless and may have trouble figuring out how to express those feelings or how to be supportive.
The options for treatment depend largely on how developed the embryo is when the woman goes in for treatment, as the size of the embryo is a main factor for determining the treatment-type. An ectopic pregnancy starts out in the unruptured state, which is when the mass is still small enough to fit in the fallopian tube. However, if left untreated for too long, the mass will continue to grow until it eventually gets so large that it will rupture the tube. All these treatments are forms of abortion. A woman's chances of survival if she does not abort are very, very slim.
If the pregnancy is discovered in the unruptured state and the patient is stable (no major bleeding problems), a drug called methotrexate can be used if the mass is less than 3.5 cm in diameter. This drug cannot be used if the embryo is too developed because it works by preventing the rapid division of cells in the early embryo; the embryo is then reabsorbed. Methotrexate can either be injected by means of a shot, IV, or transvaginally into the fallopian tube. Either single or multiple doses can be used. Side effects of methotrexate use are very minimal, including nausea and fatigue. Contraindications to the use of methotrexate include:
a) Active lung disease
b) Cardiac problems
c) Pelvic pain
d) Early indications of shock
e) White blood cell count less than 3,000
However, the pregnancy may sometimes be removed using laparoscopy, a less invasive surgical procedure. The surgeon makes small incisions in the lower abdomen and then inserts a tiny video camera and instruments through these incisions. The image from the camera is shown on a screen in the operating room, allowing the surgeon to see what’s going on inside of the body without making large incisions. The ectopic pregnancy is then surgically removed and any damaged organs are repaired or removed.
If the mass is greater than 3.5 cm and the woman is experiencing signs of blood loss and shock, surgical treatment will be required, which takes 60 minutes on average (although it can range from 13-240 minutes). There are 2 different types that can be performed:
Salpingostomy: this conservative procedure involves removal of the part of the fallopian tube that contains the fetus. It is done to maximize the preservation of the tube for subsequent fertility. The 2 ends of the cut tube are rejoined after healing has taken place. The woman should be informed that rejoining the tubes results in a decreased fertility and thus a higher rate of recurrent ectopic pregnancy.
Salpingectomy: this procedure involves the removal of the whole fallopian tube on the side where the ectopic occurred. It is done if conservative surgery is not possible, like when the tube is damaged or deformed. This procedure decreases fertility even more than salpingostomy; there is the chance of subsequent ectopic pregnancy, but not as much as with salpingostomy. It is important to understand that this surgery itself does not cause more ectopics. It is simply that women who had an ectopic because of one abnormal tube are more likely to have the same abnormality in the other tube, and thus more chance of an ectopic.
If the pregnancy is further along, you'll likely need surgery to remove the abnormal pregnancy. In the past, this was a major operation, requiring a large incision across the pelvic area. This might still be necessary in cases of emergency or extensive internal injury.
The goal of treatment is to use the least invasive method that has the highest success rate and will preserve the woman's subsequent fertility.
Here is a table that provides some useful information regarding the success rates and benefits of methotrexate versus laparoscopy.
Treatment Success Rate Post-op stay Time for HCG back to normal Subsequent pregnancy rates Fertility Differences
Methotrexate 88.2% 24 hours 29 days 50-79% Use of methotrexate results in lower rate of repeat ectopic pregnancy
Laparoscopy (salpingotomy 95.9% 46 hours 13 days 50-85%
There are other procedures to save the mother's life such as:
• Blood transfusion
• Fluids given through a vein
• Keeping warm
• Oxygen
• Raising the legs
Whatever the treatment will be, the doctor will want to see the patient regularly afterward to make sure your Human chorionic gonadotropin or Human chorionic gonadotrophin (hCG) levels return to zero,( it is a hormone produced in pregnancy that is made by the developing embryo after conception and later by the part of the placenta. Its role is to prevent the disintegration of the corpus luteum of the ovary and thereby maintain progesterone production that is critical for a pregnancy in humans. It may have additional functions; for instance, it is thought that hCG affects the immune tolerance of the pregnancy. Early pregnancy testing, in general, is based on the detection or measurement of hCG. Because hCG is produced also by some kinds of tumor, hCG is an important tumor marker). This may take several weeks. An elevated hCG could mean that some ectopic tissue was missed. This tissue may have to be removed using methotrexate or additional surgery.
After a woman has an ectopic pregnancy, her HCG (human chorionic gonadotropin) levels need to be monitored. She will need to have her levels checked 48 hours after her treatment and then once a week until they go back to being negative. The woman does not need to make a separate doctor's appointment for each of these tests; usually, she can simply walk into the doctor's office in the morning to get her blood tested. If these levels do not become negative, surgery or additional methotrexate treatment will be required. The woman will also need to use contraception for at least 3 months after her ectopic to allow the fallopian tubes time to heal (unless her tube was removed altogether). The next time she does miss a period, she needs to see a doctor right away to make sure it is not another ectopic. Her doctor will measure HCG levels and perform an ultrasound.
Terminologies
Pregnancy:
According to Dr. Ricardo Bula from the Emilia’s EBAIS. (consulted on March 11, 2010.)
“It is the carrying of one or more offspring, known as a fetus or embryo, inside the woman’s womb. Childbirth usually occurs about 38 weeks after conception; approximately 40 weeks from the last normal menstrual period in humans.”
It is when a woman has an embryo growing in her womb for a period of 38-42 weeks.
Embryo
“In humans, it is called an embryo until about eight weeks after fertilization (i.e. ten weeks LMP), and from then it is instead called a fetus.”
(According to Wikipedia, the free encyclopedia. 21 April 2010)
Uterus
According to the Virtual medical dictionary “The uterus (womb) is a hollow, pear-shaped organ located in a woman's lower abdomen between the bladder and the rectum. The narrow, lower portion of the uterus is the cervix; the broader, upper part is the corpus. The corpus is made up of two layers of tissue.”
In the womb is where the embryo is located.
Fertilized Egg
In the other hand, the free dictionary of medicine affirm that the fertilized egg in an animal organism in the early stages of growth and differentiation that in higher forms merge into fetal stages but in lower forms terminate in commencement of larval life.
This definition allows us to conclude that is the union of the spermatozoid and the egg.
Fallopian Tube
The virtual Medial dictionary says that “Fallopian tube is one of the two Fallopian tubes that transport the egg from the ovary to the uterus (the womb)”. In the diagram, the Fallopian tubes are not labeled but are well shown running between the uterus and ovaries.
Cervix
According to Doctor Marshall from Memorial Hospital South Bend, Michigan street; “the Cervix is the lower, narrow part of the uterus (womb). The uterus, a hollow, pear-shaped organ, is located in a woman's lower abdomen, between the bladder and the rectum. The cervix forms a canal that opens into the vagina, which leads to the outside of the body.
Ovary
In the same way the Doctor Marshall from Memorial Hospital affirm that the ovary is consider as the female gonad, the ovary is one of a pair of reproductive glands in women. They are located in the pelvis, one on each side of the uterus. Each ovary is about the size and shape of an almond. The ovaries produce eggs (ova) and female hormones. During each monthly menstrual cycle, an egg is released from one ovary. The egg travels from the ovary through a fallopian tube to the uterus. The ovaries are the main source of female hormones, which control the development of female body characteristics, such as the breasts, body shape, and body hair. They also regulate the menstrual cycle and pregnancy.
Blood hormone tests
According to Cathy Wong from the medical bureau of Lancaster, this hormone blood test for women evaluates hormonal balance in both pre-and post-menopausal women, using a single blood sample. And looks at: three estrogens, the balance of estrone, estradiol, and estriol; progesterone, this hormone rises and falls during the menstrual cycle, influencing fertility and PMS, and after menopause it modulates the effects of estrogens; two androgens, both testosterone and DHEA affect sexual function, body composition, and cognition; estrogen metabolites, the "2" and "16a" forms of hydroxylated estrone that have different effects on genetic expression and rate of cell proliferation, their ratio may indicate a woman's risk for breast and endometrial cancer; and the sex hormone-binding globulin (SHBG) that influences the circulating levels of free testosterone and estradiol.
Using this blood test they can know if the woman is pregnant and if everything is working in the correct way with the baby.
Laparoscopy
According to Mastery of Endoscopic and Laparoscopic Surgery W. Stephen, M.D. Eubanks Laparoscopy is an operation performed in the abdomen or pelvis through small incisions (usually 0.5–1.5cm) with the aid of a camera. It can either be used to inspect and diagnose a condition or to perform surgery.
This kind of surgery is an easy one, is not dangerous and the recuperation is very fast.
Pelvic exam:
According to Doctor Morgan from university of Pennsylvania, a Pelvic exam is an examination of the organs of the female reproductive system. In a pelvic exam, a speculum (an instrument for opening and widening certain passages of the body) is used to open the vagina and aid in visualizing the uterine cervix. A sample of cells may be taken off the surface of the cervix for a Pap smear or a sample may be obtained for laboratory culture. The uterus womb and ovaries are felt with the fingers to detect swellings or other abnormalities.
Transvaginal ultrasound
According to the book named The Medical World, Steven Carson, Florida (2006) “the transvaginal sound is a imaging technique used to create a picture of the genital tract in women”. The hand-held device that produces the ultrasound waves is inserted directly into the vagina, close to the pelvic structures, thus often producing a clearer and less distorted image than obtained through transabdominal ultrasound technology, where the probe is located externally on the skin of the abdomen.
Hormone
The Virtual Medical Dictionary says that a Hormone is “A chemical substance produced in the body that controls and regulates the activity of certain cells or organs” Many hormones are secreted by specialized glands such as the thyroid gland. Hormones are essential for every activity of daily living, including the processes of digestion, metabolism, growth, reproduction, and mood control. Many hormones, such as the neurotransmitters, are active in more than one physical process.
Intrauterine contraceptive device (IUD)
“Intrauterine contraceptive device (IUD) is a device inserted into the uterus (womb) to prevent conception (pregnancy). The IUD can be a coil, loop, triangle, or T-shape. It can be plastic or metal”.
Is one of the safest contraceptive after you already had kids. It is commonly known as the “T”.
(1996-2010 MedicineNet.com)
Fertility Drugs
“Fertility drug is a drug used to increase a woman's fertility; there are clomiphene, clomiphene citrate - a fertility drug (trade name Clomid) that is used to stimulate ovulation and that has been associated with multiple births-.”
(1996-2010 MedicineNet.com)
Prognosis
Doctor Sawyer, from the university of Pennsylvania says that “a Prognosis is defined as a prediction of the course of a disease in a patient”.
Methotrexate
“Methotrexate is a drug that acts as an antimetabolite and specifically as a folic acid antagonist that inhibits the synthesis of DNA, RNA, and protein”
(1996-2010 MedicineNet.com)
Ectopic:
It is a pregnancy that occurs in an abnormal position or place.
HCG (human chorionic gonadotropin):
It is a hormone produced during the pregnancy that is made by the developing embryo after conception and later by the part of the placenta. It’s role is to prevent the disintegration of the ovary and thereby maintain progesterone production that is critical for a pregnancy in humans.
Endometriosis: It’s the presence of uterine lining in other pelvic organs, characterized by a cyst formation, adhesions, and menstrual pains.
Estrogen: the major female sex hormones produced primarily by the ovarian, capable of inducing estrus, developing and maintaining secondary female sex characteristics, and preparing the uterus for the reception of a fertilized egg.
Progesterone: It is a hormone, which prepares the uterus for the fertilized ovum and maintains pregnancy.
Conclusions
• The first conclusion is related with the importance of take into account an unusual topic, and inform to the people about that kind of pregnancy.
• The second conclusion is about take care of yourself, when a woman fell that something is not normal with her organism, she have to look for a doctor and ask him for some exams in order to know what is wrong or what is happening with her body.
• Another conclusion is look for another way of contraceptive method because the uterine contraceptive device and the emergency contraception are factors that can risk the level or the probabilities to suffer for an ectopic pregnancy.
• The nicotine in cigarettes is bad for the human health and is important to say that it produce spasm in the womb on women.
• Also is very important to say that the procedure or the surgeries always comes to an abortion because there are not possible ways in which the fetus can be saved.
• The treatment with more success rate in those cases is the Laparoscopy (salpingotomy) so is important to know that.
Recommendations:
• Try to avoid use medications with hormones because is a factor that increase the risk for an ectopic pregnancy.
• If you suffer that kind of pregnancy is very important that you look for information and try to stay calm.
• Go to the doctor more often in order to make some control test to detect any complication at time.
• Try not to smock because nicotine is not good.
• After an ectopic pregnancy is important to visit the doctor periodically to determine and monitored the situation of the woman.
• A good option for women to suffer an ectopic pregnancy, and have problems to conceive in a normal way the doctors recommend the in vitro fertilization.
Outline
Topic: Ectopic pregnancy
I. Introduction (thesis): The ectopic pregnancy is an uncommon pregnancy with symptoms, consequences, treatments unknown for many people and this is very dangerous because this can cause dead.
II. Body paragraph
A. description of ectopic pregnancy
- How it is diagnosed
- Pelvic exam
III. Body paragraph
a. causes of an ectopic pregnancy
IV. Body paragraph
D. treatments for ectopic pregnancy
-methods
V. Body Paragraph
C. consequences
VI. Conclusion:
As you noticed, it is an unknown pregnancy for many people, it is important to take into account this information in order to be updated and paying special attention to those symptoms if something estrange happens during pregnancy.
References
- Breast Cancer Foundation (1999). Ectopic Pregnancy (On line) Retrived on 19/03/2010-10:29 pm. Address:
http://www.womenshealth.org/a/ectopic_pregnancy.htm
-Larissa Hirsch (2008). MD. Ectopic pregnancy, (on line) Retrived on 20/03/2010-02:38 pm. Address:
http://kidshealth.org/parent/pregnancy_newborn/pregnancy/ectopic.html
-American Pregnancy Association (2007). Ectopic Pregnancy (on line). Retrived on 23/03/2010-07:46 pm. Address:
http://www.americanpregnancy.org/pregnancycomplications/ectopicpregnancy.html
-Peter Chen (2008). Ectopic Pregnancy (on line). Retrived on 23/03/2010-08:12 pm. Address:
http://www.nlm.nih.gov/medlineplus/spanish/ency/article/000895.htm




